Delayed profound thrombocytopenia associated with eptifibatide

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Profound thrombocytopenia after primary exposure to eptifibatide

Eptifibatide is a glycoprotein IIb/IIIa receptor antagonist used to reduce the incidence of ischemic events in patients with acute coronary syndromes and those undergoing percutaneous coronary intervention. A minority of patients given eptifibatide develop acute, profound thrombocytopenia (<20,000 cells/mm(3)) within a few hours of receiving the drug. This case report discusses a patient who de...

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Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/IIIa.

Acute thrombocytopenia is a recognized complication of treatment with GPIIb/IIIa inhibitors whose cause is not yet known. We studied 9 patients who developed severe thrombocytopenia (platelets less than 25 x 10(9)/L) within several hours of treatment with the GPIIb/IIIa inhibitors tirofiban (4 patients) and eptifibatide (5 patients). In each patient, acute-phase serum contained a high titer (ra...

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1 Cook GC. Tropicalgastroenterology. Oxford: Oxford University Press, 1980:373,381,394. 2 Ambroise-Thomas P. Amebiasis and other protozoal diseases. In: Houba V, ed. Immunological investigation oftropical parasitic diseases. Edinburgh, London, New York: Churchill Livingstone, 1980:75-83. 3 Smith PD. Infectious agents and inflammatory bowel disease. Gastroenterologc 1983;85:475-6. 4 Gorbach SL. ...

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ژورنال

عنوان ژورنال: American Journal of Hematology

سال: 2006

ISSN: 0361-8609,1096-8652

DOI: 10.1002/ajh.20609